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KMID : 0356919950280030371
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Korean Journal of Anesthesiology
1995 Volume.28 No. 3 p.371 ~ p.375
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Salmon-Calcitonin; Analgesic Effect and Influence on the Morphine Induced Analgesia
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Abstract
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Calcitonin is a peptide hormone involved primarily in the regulation of calcium homeostasis. However, clinical observations have shown that Calcitonin does in fact possess an analgesic effect in a variety of painful disorders. So I studied the
analgesic
effect of intracerebroventricularly(i.c.v.) administered salmon calcitonin(s-CT) using the hot plate test and writhing test. The influence on the analgesia induced by morphine and naloxone reversibility was also studied. When s-CT was
administered
i.c.v., analgesia was observed in both tests, although it was greater in the writhing test than in the hot plate test. The analgesic effect of s-CT was partially but significantly reversed by naloxone. Thus, these results provide information
about
the
antinociceptive effect of s-CT via interaction with both opiate and non-opiate mechanisms.
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